Cold email software for B2B companies in Des Moines, IA
Acqro researches every company on your Des Moines target list and writes each email from what it finds. Below is verified federal data on the Polk County market that contains Des Moines, and how to turn it into an outbound list.
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How big is the B2B market in Des Moines?
Polk County, which includes Des Moines, had 13,890 business establishments in 2023, 4,318 of them with 10 to 249 employees, according to the U.S. Census Bureau. Acqro is AI cold email software that researches each target company before writing, then sends through authenticated domains with verification, warmup and throttling built in.
The Des Moines B2B market in numbers
Figures cover Polk County, Iowa, the county that contains Des Moines. County Business Patterns does not publish city-level industry detail.
- Business establishments
- 13,890+0.4% vs 2022Census CBP 2023
- Firms with 10–249 employees
- 4,318Census CBP 2023
- Paid employees
- 295,413Census CBP 2023
- Average annual pay
- $66,459Census CBP 2023
- Professional services firms
- 1,602Census CBP 2023, NAICS 54
- County GDP
- $59.6B+4.9% 2022–2023BEA CAGDP2 2023
67.8% of establishments in Polk County have fewer than 10 employees, below the 73.0% share for the United States. The 4,318 establishments with 10 to 249 employees are where most B2B lists should start: large enough to have a budget and a defined buyer, small enough that an owner or department head still makes the call and reads their own email.
By employment, the largest sectors are health care and social assistance (14.1% of jobs) and finance and insurance (13.4% of jobs). Relative to the national mix, finance and insurance (13.4% locally against 5.0% nationally) and management of companies and enterprises (4.0% locally against 2.8% nationally) stand out, which makes them natural first segments for outbound.
The number of establishments changed by +0.4% between 2022 and 2023, slower than the +0.8% change for the United States. New and growing businesses are the accounts most likely to be choosing vendors for the first time, so pair that list with research on hiring, new locations and leadership changes before writing a single email.
Which industries employ the most people in Polk County
Sectors ranked by paid employment, with each sector's share of local jobs compared with its national share.
| Sector | Establishments | Employees | Avg. annual pay | Share of jobs | US share |
|---|---|---|---|---|---|
| Health care and social assistance | 1,558 | 41,657 | $61,939 | 14.1% | 15.8% |
| Finance and insurance | 1,018 | 39,449 | $104,624 | 13.4% | 5.0% |
| Retail trade | 1,594 | 33,537 | $34,127 | 11.4% | 11.5% |
| Accommodation and food services | 1,271 | 25,640 | $24,408 | 8.7% | 10.4% |
| Professional, scientific and technical services | 1,602 | 22,015 | $94,338 | 7.5% | 7.4% |
| Manufacturing | 335 | 19,932 | $67,370 | 6.7% | 8.8% |
| Construction | 1,326 | 18,804 | $82,045 | 6.4% | 5.5% |
| Transportation and warehousing | 432 | 17,302 | $57,153 | 5.9% | 4.7% |
| Wholesale trade | 741 | 16,793 | $79,760 | 5.7% | 4.5% |
| Administrative, support and waste management services | 775 | 13,530 | $48,978 | 4.6% | 9.6% |
Des Moines businesses by company size
Company size decides who to email: owners at the smallest firms, department heads in the middle, specialist buyers at the largest.
| Company size | Establishments | Share | US share |
|---|---|---|---|
| 1 to 4 employees | 7,008 | 50.5% | 55.5% |
| 5 to 9 employees | 2,406 | 17.3% | 17.5% |
| 10 to 19 employees | 1,941 | 14.0% | 12.5% |
| 20 to 49 employees | 1,574 | 11.3% | 9.1% |
| 50 to 99 employees | 530 | 3.8% | 3.0% |
| 100 to 249 employees | 273 | 2.0% | 1.7% |
| 250 or more employees | 158 | 1.1% | 0.7% |
B2B service firms in Polk County
Establishment counts for the service industries Acqro customers most often work in. Each links to an industry-specific outreach guide.
| Industry | Census industry (NAICS) | Establishments |
|---|---|---|
| Commercial Real Estate Brokers | Offices of Real Estate Agents and Brokers | 316 |
| Law Firms | Offices of Lawyers | 312 |
| Commercial Insurance Brokers | Insurance Agencies and Brokerages | 295 |
| Management Consultants | Administrative Management and General Management Consulting Services | 147 |
| Commercial Cleaning Companies | Janitorial Services | 136 |
| CPA and Accounting Firms | Offices of Certified Public Accountants | 112 |
| Software Development Agencies | Custom Computer Programming Services | 107 |
| Staffing Agencies | Temporary Help Services | 90 |
| SEO Agencies | Marketing Consulting Services | 88 |
| Healthtech Vendors | Computer Systems Design Services | 85 |
| Financial Advisory Firms | Investment Advice | 79 |
| Architecture Firms | Architectural Services | 49 |
How to build a cold email campaign for Des Moines
Pick segments from the data
Start with the sectors that are large or over-represented locally, such as health care and social assistance and finance and insurance, and only the ones your offer genuinely fits.
Filter by company size
Narrow to the size band your product serves; Polk County has 4,318 establishments with 10 to 249 employees. A tight list of well-matched accounts outperforms a long loose one.
Verify every address
Remove hard bounces, role accounts and stale records before anything is queued. Keeping hard bounces under 2 percent protects the domains everything else depends on.
Research each company
Look for a reason to write now: hiring, a new location, a leadership change, a launch. For Des Moines prospects, local expansion news and job posts are usually the easiest signals to verify.
Send on protected infrastructure
Use secondary domains with SPF, DKIM and DMARC, warm them over three to four weeks, and keep each mailbox to 30 to 50 cold emails a day.
Cold email in Des Moines, answered
How many businesses are there in Des Moines, IA?
Polk County, which contains Des Moines, had 13,890 business establishments in 2023 employing 295,413 people. Source: U.S. Census Bureau, County Business Patterns 2023. City-level industry counts are not published, so the county is the closest official geography.
What are the largest industries in Des Moines?
By paid employment in Polk County, the largest sectors in 2023 were health care and social assistance (14.1% of jobs), finance and insurance (13.4% of jobs) and retail trade (11.4% of jobs). Source: U.S. Census Bureau, County Business Patterns 2023.
How many mid-sized companies are in Des Moines?
Polk County had 4,318 establishments with 10 to 249 employees in 2023, the size range most B2B outbound campaigns target. Source: U.S. Census Bureau, County Business Patterns 2023.
Is cold email legal in the United States?
Yes. The federal CAN-SPAM Act permits commercial email to business contacts without prior consent, provided the message identifies the sender accurately, uses a truthful subject line, includes a valid physical postal address and a working opt-out, and honours opt-out requests promptly. CAN-SPAM applies in every state and preempts most state commercial email laws, except provisions aimed at falsity or deception. This is general information, not legal advice.
What does Acqro do differently from other cold email tools?
Most cold email tools send the copy and list you provide. Acqro researches each target company's public signals first, such as hiring, funding, launches and leadership changes, and drafts each email from that evidence, with verification, authenticated sending domains, warmup and a unified reply inbox built in.
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Sources and methodology
Every figure on this page comes from a federal statistical release and is shown with its source and reference year. Figures the agencies withhold or publish with high noise are left out rather than estimated. Page updated September 17, 2026.
- U.S. Census Bureau, County Business Patterns 2023 and 2022: establishments, paid employment for the pay period including March 12, annual payroll, and establishments by employment size. Industries use NAICS 2017 codes.
- U.S. Bureau of Economic Analysis, CAGDP2: GDP by county in current dollars, 2023.
- Geography: Des Moines is located in Polk County. Figures describe the whole county.
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